A breakthrough technology of achieving combined high ion-exchange capacity and high resolution for the non-porous resins. With the particle size selection of 1.7, 3, 5 and 10 µm, Proteomix ion-exchange phases are specially designed for high resolution, high efficiency and high recovery separations of proteins, oligonucleotides and peptides. The packing support is composed of a rigid, spherical, highly cross-linked poly(styrene divinylbenzene) (PS/DVB) non-porous particle.