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SepTech 10-C18 media was specifically engineered for use in preparative to process HPLC. The two pore sizes, 60Å and 150Å, have been optimized to give high capacity for small molecules and larger natural molecules and peptides, respectively. The bulk media is available for packing small-scale purification and process development columns, such as the bench top Load & Lock hardware and in larger quantities for subsequent production columns. For laboratories that prefer to use pre-packed preparative columns for small-scale work, Varian now offers the SepTech media pre-packed in Dynamax hardware. The Dynamax hardware is a unique patented design, which is ideally suited to small-scale and prep/process development. The principle of operation is dynamic axial compression, which maintains the packed bed integrity and eliminates voids - providing a high performance column over a longer period of time. It is a component system, a pre-packed compression module, onto which the Dynamax end fitting hardware is easily installed. The end fitting hardware can be re-used on any Dynamax module of the same diameter, so reducing the preparative column hardware costs.
By providing SepTech 10-C18 media packed in the Dynamax hardware, Varian is able to offer a pre-packed prep column for small scale purifications and process development which is convenient and cost effective to use. As the columns utilize DAC technology, methods developed on the Dynamax columns will directly scale up to full production when linear scale up is applied.
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