Alpha-Burke 2 Series

The Regis α-Burke 2 phase, first prepared by J. A. Burke III, a graduate student of Dr. Pirkle, is derived from dimethyl N-3,5-dinitro-benzoyl-α-amino-2,2-dimethyl-4-pentenyl phosphonate. The α-Burke 2 has been specifically designed to directly separate the enantiomers of β-blockers without chemical derivatization, but this chiral phase is not limited solely to the separation of β-blocker enantiomers. It also resolves the enantiomers of many compounds separated on π-acceptor Pirkle type chiral stationary phases.