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VYDAC DENALI columns contain a new-generation silica-based 120Å monomeric C18 adsorbent based on the same bonding technology employed in Vydac EVEREST 300Å columns. This new technology improves C18 surface coverage and deactivates residual silanols. VYDAC DENALI C18 carbon coverage is 4 μmol/m2 and approximates the theoretical limit based on surface area. VYDAC DENALI columns provide excellent separations for small-molecule analytes.