COSMOCORE Cholester (similar to C18 plus Shape Selectivity)

Core-shell particles consist of a nonporous core inside a porous shell. By using these core-shell particles, one can achieve sharper peaks compared to fully porous silica gel particles of the same diameter. Compared to fully porous particles, core-shell particles have a more uniform particle diameter therefore, core-shell particles can be packed in the column more uniformly to minimize sample diffusion.

Cholester is a silica-based reversed-phase column using cholesterol as the bonded phase. It has similar hydrophobicity to C18 (ODS) and, with superior stereoselectivity, it is suitable for compounds with similar hydrophobicity but slightly different molecularshape. COSMOCORE 2.6Cholester offers improved separation for cis-trans isomers than C18 under typical reversed-phase mobile phase. COSMOCORE 2.6Cholester has about the same hydrophobicity as C18. It is not necessary to change the analytical conditions when replacing C18 Columns with COSMOCORE 2.6Cholester. COSMOCORE 2.6Cholester has excellent shape slectivity due to its structural rigidity. COSMOCORE 2.6Cholester has the same functional group as the fully-porous COSMOSIL Cholester 5µm, therefore the separation pattern in COSMOCORE 2.6Cholester is maintained when scaling up to preparative separation with 5µm COSMOSIL Cholester.