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ZirChrom-MS is a "deactivated" zirconia-based reversed-phase column that has mixed mode retention characteristics which allow for LC/MS chromatography of highly basic amines with excellent peak shape and efficiency using conventional LC/MS buffer systems. ZirChrom-MS provides the traditional unique selectivity of zirconia on a low bleed HPLC stationary phase. The high stationary phase loading of ZirChrom-MS allows users to increase the organic content of their mobile phase, leading to greater LC/MS sensitivity.