ZirChrom-EZ (Lewis Acid Deactivated)

ZirChrom-EZ provides the traditional unique selectivity of zirconia while facilitating the buffer selection process in the pH range of 1-10. This new ease-of-use capability, along with its orthogonal selectivity for pharmaceutical compounds, makes ZirChrom-EZ well suited for LC/MS applications.

Historically, the Lewis base carboxylic acid moiety on non-steroidal anti-inflammatory drugs required the use of a Lewis base mobile phase additive of a higher strength in the elutropic series (such as phosphate or fluoride). While these types of additives work well in applications with UV/Vis detection, their use is almost entirely prohibited in LC/MS applications due to their relatively low volatility. The deactivation of Lewis acid sites on the surface of the ZirChrom-EZ particle allows the chromatography of Lewis base analytes using mobile phase additives of the user’s choice including conventional LC/MS compatible buffers (such as acetate and formate) throughout the pH range of 1-10.

• Easy-To-Use
• Unique Selectivity
• Wide Applicability
• Low Bleed for LC/MS