Proteonavi was developed to separate proteins and peptides in reversed phase mode.
Adsorption to a stationary phase is one of the most common limiting factors in protein separation in reversed-phase mode. It is generally understood that the irreversible adsorption is caused by denaturing of protein in the hydrophobic phase or a coulombic interaction with silica, a chromatographic support. Proteonavi has overcome the problem by introducing the short fourcarbon structure on the silica surface with a unique chemistry. Its synthetic process has already been established for even a large industrial-scale purification.