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SampliQ C8/Si-SCX

The use of mixed-mode stationary phases is widely accepted for the extraction of basic drugs from biological fluids. The SampliQ Mixed-Mode Reversed-Phase SPE product consists of an alkyl phase (C8) and a strong cation exchange phase (Si-SCX) in an optimized ratio that provides a dual retention mechanism. The C8 functionality interacts with the hydrophobic portions of an analyte while the Si-SCX functionality interacts with the protonated amine portion. The strong analyte interactions allow the use of more rigorous washing conditions to eliminate co-extractables that might interfere with UV detection or cause ion suppression effects in LC-MS. The SampliQ Mixed-Mode phase is manufactured with trifunctional silanes allowing for maximum stability and low leachability. The phase is non-endcapped which gives some added interaction between residual silanols and polar analytes helping to provide added retention characteristics.

        
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