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Welch Ultisil® Diol Column is based on ultra-pure porous spherical silica bonded with 1,2-dihydroxypropyl functional group silica Ultisil® Diol is used in normal phase mostly, suitable for separation of peptides, proteins, polar molecules, and organic acids and its polymers. Like bare silica, Ultisil® Diol has the ability to form hydrogen bonds and is capable of separating structure isomers. Since most
of its surface is covered with organic functions, Ultisil® Diol absorbs less water, which leads to more reproducible activity. It is also the sorbent of choice when working in normal phase in the presence of water. It has a different selectivity than bare silica gel, and slight modification in the composition of solvent mixture may be necessary to obtain a similar retention. Ultisil® Diol column is more stable than traditional normal phase columns, such as NH2 , SiO2 . Compared with NH2/SiO2 column, Diol column is not sensitive to water. Ultisil® Diol column can also be used in reversed phase analysis.
