Acclaim Trinity P1 Series (Mixed Mode RP-AX-CX)

Mixed mode column technology combining reversed-phase, anion exchange and cation exchange functionality on a single support

The Thermo Scientific™ Acclaim™ Trinity™ P1 HPLC column is designed with Nanopolymer Silica Hybrid (NSH) technology, which results in a multimode surface chemistry ideal for the simultaneous separation of drugs and their counterions. The surface chemistry concurrently provides reversed-phase, cation exchange, and anion exchange functionalities. The result is maximum flexibility in method development. Separations can be optimized easily by adjusting the chromatographic parameters (mobile phase pH, ionic strength, and organic strength).

• Ideal selectivity for simultaneous separation of API and counterion
• Adjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solvent
• Low bleed; compatible with MS, CAD and ELSD
• Retention of hydrophilic ionic and ionizable analytes without ion-pairing reagents
• Greater flexibility in method development: each retention mechanisms can be controlled independently