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The Thermo Scientific Acclaim Mixed-Mode HILIC-1 column features a unique, high-efficiency, silica-based HPLC mixed-mode stationary phase that combines both reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC) properties. This combination allows both hydrophobic and hydrophilic interactions to be utilized to optimize separations. The functional group is of a hydrophobic alkyl chain with a diol group at the terminus. This unique combination results in the adjustable selectivity, making Acclaim Mixed-Mode HILIC-1 separate mixtures that would be impossible for a C18 column. This column is suitable for a broad range of applications, including non-ionic ethoxylated surfactants, drug metabolites, lipids, polyethylene glycols (PEGs), ethoxylated surfactants, and more.
Can operate in both RP and HILIC modes
Retains highly polar molecules
Unique selectivity complementary to RP columns
Broader application range compared with conventional diol-based columns
