Hypercarb Series (Porous Graphitic Carbon)

Thermo Scientific Hypercarb, Porous graphitic carbon (PGC) has uniqueproperties as a stationary phase in high performance liquidchromatography (HPLC). Its chemical surface propertiesdistinguish Porous graphitic carbon (PGC) from more conventional HPLC packings suchas bonded-silica gels and polymers. Porous graphitic carbon (PGC) behaves as astrongly retentive alkyl-bonded silica gel for non-polar analytes, however its retention and selectivity behaviourtowards polar and structurally related compounds is verydifferent. Porous graphitic carbon (PGC) provides unique retention and separation ofvery polar compounds.

Its surface is stereo-selective withthe capability to separate geometric isomers, diastereomersand other closely related compounds. Hypercarb is stablethroughout the entire pH range 0-14, and is not affected byaggressive mobile phases. Its compatibility with all solventsystems enables separation of a wide range of polaritieswithin a single chromatographic run. The selectivity of the Hypercarb packing is different from the selectivity of silicaand polymeric phases. Its retention mechanism is differentfrom conventional C18 columns.

Hypercarb Application Notebook