Clean-Up® THX (Thiopropyl)

Covalent sorbents have either epoxy, aldehyde, isocyanate or thiopropyl functional groups that are bound to the silica backbone by a hydrocarbon chain. These groups will react selectively with analyte functional groups forming a covalent bond between the stationary support and the analyte. In the case of the aldehyde sorbent, an analyte with a primary amine performs a nucleophilic attack on the aldehyde functionality in the sorbent. This reaction results in a Schiff base, with the amine immobilized on the stationary support. This chemistry can be utilized to bind proteins, such as antibodies, to the support, allowing highly specific extractions.

Application: The thiopropyl functional group scavenges for alkylating agents, alcohols and amines.